What Causes Urinary Incontinence? Urinary incontinence is not a disease. It is a symptom of a wide range of conditions. These may include diabetes, stroke, multiple sclerosis, Parkinson’s disease, some surgeries or even childbirth or menopause* for women. Certain types of medications can cause or make incontinence worse. These medications include diuretics, sedatives, narcotics, antidepressants, antihistamines, calcium channel-blockers and alpha-blockers. In men, the most common cause of incontinence is surgery of the prostate. There are three different types of incontinence.